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KMID : 0352419950140030239
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Keimyung Medical Journal
1995 Volume.14 No. 3 p.239 ~ p.243
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Effect of Ipriflavone on Bone Mass and Biochemical Bone Markers in Postmenopausal Women
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Abstract
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A study in postmenopausal women was performed to assess the effect of treatment with ipriflavone for twelve months on bone mass and biochemical bone markers.
Fifty-two women with diagnosis of postmenopausal osteoporosis were treated with ipriflavone (600mg/day) (IP) or placebo(PL).
After 12 months, a significant increases(2%, P<0.05) of bone mineral density at the second lumbar vertebra was obtained in the IP-group. Serum osteocalcin and urinary HOP/Cr values were reduced in the same group. Bone mineral density did not
change(-0.7%. P<0.05) in the PL group. Serum osteocalcin and urinary HOP/Cr values were increased (P<0.01) in the same group.
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